Yohko Mano may seem like a typical high school girl. She is sixteen years old, athletic, pretty, and boy crazy. She lives in a nice house with her mom and her grandmother. But once you get past that, Yohko is hardly normal. Many of the female members of the Mano family have been mamono hunters, fighting evil spirits and demons throughout history. Over the years, they have been successful in preventing evil from taking over mankind. Yohko learns that she was able to escape the earlier attack because her powers have been manifesting as she grew up, and that now she is indeed the 108th generation mamono hunter.